Acute interstitial nephritis secondary to esomeprazole.

The Medical Journal of Australia ISSN: 0025729X 7 March 2005 182 5 235-236 ©The Medical Journal of Australia 2005 www.mja.com.au Lessons from practice nephritis induced by esomeprazole, along with six renal failure and two of renal impairment. In October 2004, the manufacturer of esomep Zeneca, reported being aware of at least 15 cases acute interstitial nephritis possibly induced by esom at least 200 cases worldwide induced by omeprazole Astra-Zeneca). Two of these esomeprazole cases a n wa wa functi I these two cases of acute interstitial nephritis, esomeprazole s implicated as the likely causative agent (although Patient 2 s also briefly exposed to rabeprazole). In both cases, renal on improved after esomeprazole was withdrawn and corticosteroid treatment begun, although Patient 2 went on to require long-term dialysis. Omeprazole was first implicated as a cause of acute interstitial nephritis in 1992. Since then, 22 case reports of omeprazoleinduced acute interstitial nephritis have been referenced in Medline. Recently, pantoprazole and lansoprazole have also been implicated as causes of acute interstitial nephritis, along with rabeprazole (unpublished data from our centre). Before the cases reported here, the Adverse Drug Reactions Advisory Committee (ADRAC) had been notified of four cases of acute interstitial cases of acute